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Updated: Feb 3, 2026

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
Published on: July 18, 2019
Convection-Enhanced Delivery in the Treatment of Glioblastoma
Objective:
To describe the indications for convection-enhanced delivery in the treatment of glioblastoma, highlighting candidates for the delivery method, mechanics of drug delivery, and management of acute and long-term complications.
Data Sources:
A conceptual framework drawn from published literature as well as author's expert experiences.
Conclusion:
Convection-enhanced delivery is an established method of delivering new therapies to patients with glioblastoma. Management of both acute and long-term complications is often drug dependent.
Implications For Nursing Practice:
Nurses should be able to recognize and manage potential complications during the infusion of agents delivered via convection-enhanced delivery. Post-infusion symptoms may worsen because of immunologic responses related to the drug and management should be directed toward symptom relief and support without interference on the immunologic response.
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