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Updated: Feb 3, 2026
08:19
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
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In Vivo Experimental Study of Noninvasive Insulin Microinjection through Hollow Si Microneedle Array
Drago Resnik1, Matej Možek2, Borut Pečar3
1Laboratory of Microsensor Structures and Electronics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, SI-1000 Ljubljana, Slovenia. drago.resnik@fe.uni-lj.si.
Micromachines
|November 6, 2018
Summary
Hollow microneedle arrays enable efficient in vivo insulin delivery in humans. This novel microneedle technology demonstrates effective drug transfer, mimicking multiple insulin doses for stable plasma concentrations.
Area of Science:
- Biomedical Engineering
- Drug Delivery Systems
- Endocrinology
Background:
- Transdermal drug delivery faces challenges with skin barrier penetration.
- Microneedle technology offers a potential solution for enhanced drug absorption.
- Efficient in vivo insulin delivery is crucial for diabetes management.
Purpose of the Study:
- To investigate in vivo insulin delivery using hollow silicon microneedle arrays.
- To evaluate drug transfer efficiency and influence of delivery parameters.
- To assess the pharmacokinetic profile of insulin delivered via microneedles.
Main Methods:
- Fabrication of a hollow microneedle array (MNA) using microfabrication.
- In vivo characterization of MNA delivery efficiency with model drugs.
- Administration of fast-acting insulin to a human subject and blood analysis.
Main Results:
- Epidermal absorption limits transfer efficiency, but MNA facilitates transport.
- Insulin delivery (100-200 IU/mL) via MNA showed significant serum insulin increase (40-50%).
- MNA delivery achieved a steady state insulin plasma concentration, mimicking multiple dosing.
Conclusions:
- Hollow microneedle arrays are effective for in vivo insulin delivery in humans.
- This method provides a promising alternative for insulin administration, improving drug bioavailability.
- The technology mimics a multiple dose regimen, offering potential for improved glycemic control.
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