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Surface CD200 and CD200R antigens on lymphocytes in advanced gastric cancer: a new potential target for immunotherapy

Witold Zgodziński1, Ewelina Grywalska2, Agata Surdacka2

  • 12 Department of General, Gastrointestinal Surgery and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, Lublin, Poland.

Archives of Medical Science : AMS
|November 6, 2018
PubMed
Abstract

Insights

Gastric cancer patients show higher CD200 expression on lymphocytes, suggesting this pathway

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality globally.
  • The CD200/CD200R pathway regulates immune responses and is implicated in suppressing anti-tumor immunity.
  • The role of this pathway in GC pathogenesis remains largely unexplored.

Purpose of the Study:

  • To investigate the frequencies of CD200 and CD200 receptor (CD200R) expressing lymphocytes in patients with gastric cancer.
  • To determine the potential association of CD200/CD200R expression with GC.

Main Methods:

  • Peripheral blood lymphocytes from 40 GC patients and 20 healthy controls were analyzed.
  • Flow cytometry was employed to quantify CD200 and CD200R expression on T (CD3+, CD4+, CD8+) and B (CD19+) cells.

Main Results:

  • GC patients exhibited significantly higher percentages of CD200+ T and B lymphocytes compared to controls.
  • Conversely, GC patients showed significantly lower frequencies of CD200R+ T and B lymphocytes.
  • No correlation was observed between CD200/CD200R expression and tumor stage or grade.

Conclusions:

  • Deregulation of the CD200/CD200R axis is significant in gastric cancer pathogenesis.
  • Elevated CD200 expression on lymphocytes may promote chronic inflammation and contribute to gastric carcinogenesis.
  • The findings highlight the CD200/CD200R pathway as a potential target in GC.
Keywords:
CD200CD200R moleculesgastric cancerlymphocytes

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