Abnormal lymphocyte protein synthesis in bronchogenic carcinoma
Cancer
|December 1, 1977
Summary
Lymphocyte protein synthesis is significantly decreased in patients with bronchogenic carcinoma. This impairment in protein synthesis is not due to a lower number of T-cells, suggesting a sensitive measure of lymphocyte function.
Area of Science:
- Immunology
- Oncology
Background:
- Bronchogenic carcinoma, a type of lung cancer, can affect immune function.
- Assessing lymphocyte function is crucial for understanding cancer-related immune responses.
Purpose of the Study:
- To investigate lymphocyte protein synthesis in patients with newly diagnosed, untreated bronchogenic carcinoma.
- To compare protein synthesis in cancer patients versus healthy controls.
- To determine if T-cell numbers correlate with observed protein synthesis abnormalities.
Main Methods:
- In vitro measurement of phytohemagglutinin (PHA)-stimulated lymphocyte protein synthesis.
- Comparison of protein synthesis between 21 lung cancer patients and 11 controls.
- Measurement of circulating E-rosetting forming cells (T-cells) in both groups.
Main Results:
- Significantly decreased absolute protein synthesis was observed in both baseline and PHA-stimulated cultures of cancer patients.
- No significant difference in in vitro DNA synthesis was found between cancer patients and controls.
- The percentage of T-cells did not differ significantly between the groups, ruling out T-cell deficiency as the cause.
Conclusions:
- Lymphocyte protein synthesis is demonstrably abnormal in patients with bronchogenic carcinoma.
- The observed abnormality in protein synthesis is independent of T-cell numbers.
- Measuring lymphocyte protein synthesis may be a more sensitive indicator of cellular immunity impairment than standard assays.
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