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Updated: Feb 3, 2026

Phase Contrast and Differential Interference Contrast DIC Microscopy
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Phase Contrast and Differential Interference Contrast DIC Microscopy

Published on: August 6, 2008

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Minimizing radiographic contrast administration during coronary angiography using a novel contrast reduction system:

Hitinder S Gurm1, Kreton Mavromatis2, Barry Bertolet3

  • 1Department of Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|November 6, 2018
PubMed

Insights

The DyeVert™ Plus Contrast Reduction System significantly reduced contrast media volume (CMV) by 40.1% in patients with chronic kidney disease (CKD) undergoing cardiac procedures. This system effectively minimizes CMV while preserving image quality, aiding in kidney protection.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Devices

Background:

  • Current guidelines emphasize minimizing contrast media volume (CMV) in chronic kidney disease (CKD) patients undergoing cardiac procedures.
  • The DyeVert™ Plus Contrast Reduction System is an FDA-cleared device designed to reduce CMV during angiography and enable real-time CMV monitoring.

Purpose of the Study:

  • To evaluate the contrast media volume (CMV) saved using the DyeVert™ Plus Contrast Reduction System in patients undergoing diagnostic coronary angiogram (CAG) and/or percutaneous coronary intervention (PCI) with manual injections.

Main Methods:

  • A multicenter, single-arm, observational study was conducted.
  • 114 patients with baseline eGFR 20-60 mL/min/1.73 m² were enrolled.
  • The primary endpoint was the percentage of CMV saved; secondary objectives included evaluating adverse events.

Main Results:

  • An overall CMV savings of 40.1% (P < 0.0001) was achieved per procedure.
  • Mean CMV delivered was 67 ± 51 mL, compared to 112 ± 85 mL attempted.
  • Image quality was maintained in all but one case; no DyeVert Plus System-related adverse events were reported.

Conclusions:

  • The DyeVert Plus System demonstrates clinically meaningful CMV savings in CKD patients undergoing CAG/PCI.
  • The system effectively maintains image quality during these procedures.
  • Data suggest the system aids in reducing contrast-induced nephropathy risk.
Abstract

Keywords:
ANCO-angiographyCONT-contrast agentsIAF-imagingPCI-percutaneous coronary interventionRDAC-renal disease-acuteangiographic/fluoroscopiccoronary

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