Related Experiment Video
Updated: Feb 3, 2026
The Cultivation, Growth, and Viability of Lactic Acid Bacteria: A Quality Control Perspective
Published on: June 16, 2022
A current approach to the control of filamentous fungal growth in media: microparticle enhanced cultivation technique
Ercan Karahalil1, Hasan Bugra Coban2,3, Irfan Turhan1
1a Department of Food Engineering , Akdeniz University , Antalya , Turkey.
Abstract:
Various strategies have been carried out to date in order to overcome the problem of the adverse effects of bulk fungal growth in bioreactors. Nevertheless, previous conventional methods such as modifying the cultivation temperature or pH resulted in limited biomass production and consequently lower yields. In recent years microparticle enhanced cultivation (MPEC) techniques are one of the most remarkable and novel methods employed for submerged fungal production to overcome bulk microbial growth. In addition to low cost advantages, MPEC also provides benefits such as not interfering with fungal metabolism, enhancing final product concentration and improving homogeneity in the fermentation broth. In this review, a comparison of conventional and novel methods to control fungal morphology has been discussed. Additionally, the application of microparticles in fungal fermentations, their benefits to the process in terms of fungal morphology, biomass accumulation, substrate consumption, and product formation also effect mechanisms of microparticle function are discussed in detail.
Insights
Microparticle enhanced cultivation (MPEC) offers a novel solution to control bulk fungal growth in bioreactors, improving biomass production and yields unlike conventional methods. This technique enhances fungal fermentation without interfering with metabolism.
Area of Science:
- Biotechnology
- Industrial Microbiology
- Bioprocess Engineering
Background:
- Bulk fungal growth in bioreactors presents challenges, limiting biomass production and yields.
- Conventional methods like altering temperature or pH have proven insufficient for optimal submerged fungal production.
Purpose of the Study:
- To review and compare conventional and novel strategies for controlling fungal morphology in bioreactors.
- To detail the application and benefits of microparticle enhanced cultivation (MPEC) in fungal fermentations.
Main Methods:
- Comparative analysis of traditional cultivation techniques versus microparticle-enhanced cultivation (MPEC).
- Detailed discussion on the mechanisms of microparticle function in fungal fermentation processes.
Main Results:
- MPEC techniques effectively overcome bulk microbial growth issues in submerged fungal production.
- MPEC offers advantages including low cost, enhanced final product concentration, and improved broth homogeneity.
- Microparticles do not interfere with fungal metabolism while improving biomass accumulation and substrate consumption.
Conclusions:
- Microparticle enhanced cultivation (MPEC) is a promising novel method for optimizing fungal fermentation.
- MPEC provides significant benefits over conventional methods for fungal biomass and product yield.
- Further understanding of microparticle mechanisms can advance bioprocess development for fungal production.
Related Concept Videos
01:27Microbial Growth Media
01:27Controlled-Current Coulometry: Overview
01:30Current Growth And Decay In RL Circuits
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
01:29Methods for Controlling Microbial Growth
01:18Controlled-Current Coulometry: Coulometric Titration
The fundamental requirements for coulometric titrations are (1) 100% efficiency in the reagent-generating electrode reaction and (2) a stoichiometric and preferably rapid reaction between the generated...