Related Experiment Video

Updated: Feb 3, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.8K

Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery

Xiao Xiao1, James Trevor Oswald2, Ting Wang3

  • 1School of Pharmacy, Jilin Medical University, Jilin, 132013, China.

Current Medicinal Chemistry
|November 6, 2018
PubMed

Insights

Platinum-based drugs are crucial for cancer treatment but face challenges. Nanotechnology-based drug delivery systems offer a promising solution to improve efficacy and reduce side effects for platinum compounds.

Area of Science:

  • Oncology
  • Materials Science
  • Nanotechnology

Background:

  • Platinum-based drugs are vital chemotherapeutics for solid tumors.
  • Clinical use is hindered by significant side effects and acquired drug resistance.
  • Novel drug delivery systems are essential to overcome these limitations.

Purpose of the Study:

  • To review current drug delivery systems for platinum-based compounds.
  • To explore advancements in nanotechnology for platinum drug delivery.
  • To evaluate combinational therapy strategies using platinum drugs.

Main Methods:

  • Review of literature on platinum-based drug delivery systems.
  • Analysis of nanotechnology applications (liposomes, dendrimers, polymers, nanotubes).
  • Evaluation of combinational therapeutic approaches.

Main Results:

  • Nanotechnology-based delivery systems show potential for targeted platinum delivery.
  • Nano-formulations can mitigate unwanted side effects and drug resistance.
  • Combinational therapy enhances the anti-tumor efficacy of platinum drugs.

Conclusions:

  • Nanotechnology offers a promising platform for developing safer and more effective platinum-based cancer therapies.
  • Targeted delivery and combinational strategies are key to improving treatment outcomes.
  • Further research into nano-formulations can optimize platinum drug utilization.
Keywords:
Drug deliveryanti-tumor drugsdrug combinationnanoparticlenanotechnology-based deliveryplatinum drug.

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.5K

Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
296
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.1K
Molecules and Compounds02:38

Molecules and Compounds

Atoms and Molecules
68.7K
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
852
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.9K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.8K