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Epidemiology of cerebral palsy in Bangladesh: a population-based surveillance study
Gulam Khandaker1,2,3,4, Mohammad Muhit2,3, Tasneem Karim1,2,3
1Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Insights
Cerebral palsy (CP) affects 3.4 per 1000 children in Bangladesh, with delayed diagnoses and limited rehabilitation services. Many children with CP have preventable risk factors, highlighting a significant public health concern.
Area of Science:
- Pediatrics
- Neurology
- Public Health
Background:
- Cerebral palsy (CP) is a significant developmental disorder with varying prevalence globally.
- Understanding the epidemiology of CP in low- and middle-income countries like Bangladesh is crucial for targeted interventions.
Purpose of the Study:
- To determine the prevalence, clinical features, and risk factors of cerebral palsy (CP) in children within Bangladesh.
- To assess the timeliness of diagnosis and access to rehabilitation services for children with CP.
Main Methods:
- Utilized the Bangladesh CP Register, a population-based surveillance database, for case identification.
- Applied established criteria (Surveillance of CP in Europe and Australian CP Register) for case definition following clinical assessments.
Main Results:
- Identified a prevalence of 3.4 per 1000 children, estimating over 233,000 children with CP in Bangladesh.
- Found that 79.6% had spastic CP, and a high percentage (79.6%) had associated impairments (e.g., speech, intellectual, epilepsy).
- Revealed delayed diagnosis (mean age 5 years 2 months) and limited access to rehabilitation (78.2% never received it).
Conclusions:
- Bangladesh faces a substantial burden of cerebral palsy, characterized by delayed diagnosis and a lack of essential services.
- A significant proportion of children with CP present with preventable risk factors, underscoring the need for improved maternal and child health initiatives.
- Urgent interventions are required to improve early detection, access to rehabilitation, and support systems for children with CP and their families in Bangladesh.
Aim:
To examine the prevalence, clinical characteristics, and risk factors of cerebral palsy (CP) in children in Bangladesh.
Method:
The Bangladesh CP Register is an ongoing population-based surveillance database of children with CP from a geographically defined area in Bangladesh. Cases were defined based on Surveillance of CP in Europe and Australian CP Register criteria after clinical assessments and identification by the key informant's method.
Results:
In total, 726 children with CP were identified between January 2015 and December 2016. Mean age was 7 years 7 months (standard deviation [SD] 4y 6mo; range: 4.8mo-18y; median 7y 1.2mo; 61.8% male, 38.2% female). Mean age at CP diagnosis was 5 years 2 months (SD 3.8). Observed prevalence was 3.4 per 1000 children (95% confidence interval [CI]: 3.2-3.7), resulting in an estimated 233 514 children (95% CI: 219 778-254 118) with CP in Bangladesh. The majority (79.6%) had spastic CP. Altogether, 79.6% of the children with CP had at least one associated impairment (speech 67.6%, intellectual 39.0%, epilepsy 23.7%, visual 10.2%, and hearing 10.2%). In total, 78.2% never received rehabilitation.
Interpretation:
In Bangladesh, the burden of CP is high, and diagnosis is substantially delayed, limiting opportunities for early intervention. There is a lack of available services and the majority of the children had preventable risk factors.
What This Paper Adds:
Prevalence of cerebral palsy (CP) is 3.4 per 1000 children in rural Bangladesh. There are an estimated 233 514 children with CP in Bangladesh. The majority have potentially preventable risk factors. Diagnosis of CP is delayed, limiting opportunities for early intervention. There is a lack of available services for children with CP in rural Bangladesh.
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