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Related Concept Videos

Venous Return01:04

Venous Return

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The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
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Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
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Venous Thrombosis I: Introduction01:30

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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Related Experiment Video

Updated: Feb 3, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
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Sulodexide in venous disease.

B J Carroll1, G Piazza2, S Z Goldhaber2

  • 1Division of Cardiovascular Medicine, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Journal of Thrombosis and Haemostasis : JTH
|November 6, 2018
PubMed
Summary

Sulodexide, a unique glycosaminoglycan, offers significant benefits for venous diseases. Its diverse pharmacological actions promote vascular health, aiding in conditions like chronic venous insufficiency and preventing blood clots with minimal bleeding risk.

Keywords:
anticoagulantsendotheliumpost-thrombotic syndromevaricose ulcervenous thromboembolism

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Area of Science:

  • Pharmacology
  • Vascular Biology
  • Biochemistry

Background:

  • Sulodexide is a glycosaminoglycan derived from porcine intestinal mucosa.
  • It possesses a complex pharmacological profile impacting the vascular system.

Purpose of the Study:

  • To review the pharmacological actions of sulodexide.
  • To discuss its clinical applications in managing venous diseases.

Main Methods:

  • Literature review of sulodexide's properties and clinical studies.
  • Analysis of its biological effects on the vascular system.

Main Results:

  • Sulodexide exhibits antithrombotic, profibrinolytic, anti-inflammatory, endothelial protective, and vasoregulatory effects.
  • It shows potential in treating chronic venous insufficiency, including venous ulceration.
  • Effective in preventing recurrent venous thromboembolism with a low risk of major bleeding.

Conclusions:

  • Sulodexide's pleiotropic vascular effects support its use in common venous disorders.
  • It represents a promising therapeutic option for venous disease management.