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Sulodexide in venous disease.
B J Carroll1, G Piazza2, S Z Goldhaber2
1Division of Cardiovascular Medicine, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Journal of Thrombosis and Haemostasis : JTH
|November 6, 2018
Summary
Sulodexide, a unique glycosaminoglycan, offers significant benefits for venous diseases. Its diverse pharmacological actions promote vascular health, aiding in conditions like chronic venous insufficiency and preventing blood clots with minimal bleeding risk.
Area of Science:
- Pharmacology
- Vascular Biology
- Biochemistry
Background:
- Sulodexide is a glycosaminoglycan derived from porcine intestinal mucosa.
- It possesses a complex pharmacological profile impacting the vascular system.
Purpose of the Study:
- To review the pharmacological actions of sulodexide.
- To discuss its clinical applications in managing venous diseases.
Main Methods:
- Literature review of sulodexide's properties and clinical studies.
- Analysis of its biological effects on the vascular system.
Main Results:
- Sulodexide exhibits antithrombotic, profibrinolytic, anti-inflammatory, endothelial protective, and vasoregulatory effects.
- It shows potential in treating chronic venous insufficiency, including venous ulceration.
- Effective in preventing recurrent venous thromboembolism with a low risk of major bleeding.
Conclusions:
- Sulodexide's pleiotropic vascular effects support its use in common venous disorders.
- It represents a promising therapeutic option for venous disease management.
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