Genetic Characterization of Neosartorin Biosynthesis Provides Insight into Heterodimeric Natural Product Generation
Yudai Matsuda1,2, Charlotte H Gotfredsen3, Thomas O Larsen1
1Department of Biotechnology and Biomedicine , Technical University of Denmark , Søltofts Plads, 2800 Kongens Lyngby , Denmark.
Abstract:
A biosynthetic gene cluster of the fungal xanthone heterodimer neosartorin (1) was discovered in Aspergillus novofumigatus, and its biosynthesis was investigated by a series of gene-deletion experiments. The results indicate that the two monomeric units of 1 are synthesized by the same set of enzymes, with chrysophanol (5) as a common precursor. Furthermore, the P450 monooxygenase NsrP for the heterodimerization was discovered, which also accepts non-native substrates to afford novel xanthone dimers.
Related Concept Videos
What is Natural Selection?
Biosynthesis in Bacteria
Biosynthesis of Polysaccharides
Biosynthesis of Lipids
Biosynthesis of Nucleic Acids
What is Population Genetics?


