Related Experiment Video
Updated: Feb 3, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
9.1K
CD38 as an immunotherapeutic target in multiple myeloma
Francesca Bonello1, Mattia D'Agostino1, Maria Moscvin1
1a Myeloma Unit, Division of Hematology , University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino , Torino , Italy.
Expert Opinion on Biological Therapy
|November 6, 2018
Summary
New immunotherapies targeting CD38 are improving outcomes for multiple myeloma (MM), an incurable blood cancer. While monoclonal antibodies show promise, other strategies like CAR T-cells are in early development.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Multiple myeloma (MM) is an incurable hematologic malignancy with variable prognosis.
- Recent advances in MM biology and drug development have improved survival, but new strategies are still needed.
- CD38 is a highly expressed target on MM cells, making it a key target for immunotherapy.
Purpose of the Study:
- To review preclinical and clinical data on CD38-targeting immunotherapies for MM.
- To discuss the evolving treatment landscape for MM utilizing CD38-directed approaches.
Main Methods:
- Review of preclinical studies and clinical trials involving CD38-targeting agents.
- Analysis of current and emerging immunotherapeutic strategies in multiple myeloma.
Main Results:
- Anti-CD38 monoclonal antibodies (mAbs) are significantly improving MM treatment outcomes, especially in combination therapies.
- Conjugated anti-CD38 mAbs, bispecific antibodies, and CD38-specific CAR T-cells represent promising, albeit earlier-stage, therapeutic strategies.
Conclusions:
- CD38-targeting immunotherapies, particularly mAbs, are transforming MM treatment.
- Further development of novel CD38-directed therapies holds potential for advancing MM care.
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