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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Growth hormone and chronic kidney disease
Anil K Pasupulati1, Ram K Menon2
1Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Current Opinion in Nephrology and Hypertension
|November 6, 2018
Summary
Elevated growth hormone (GH) levels contribute to kidney damage in diabetes and acromegaly by harming podocytes. Understanding GH
Area of Science:
- Nephrology
- Endocrinology
- Cell Biology
Background:
- Growth hormone (GH) excess is linked to kidney disease, characterized by hyperfiltration, glomerular hypertrophy, glomerulosclerosis, and albuminuria.
- Conversely, reduced GH secretion or action offers protection against glomerulopathy.
- Recent research highlights GH's direct impact on glomerular cells, especially podocytes.
Purpose of the Study:
- To review the emerging role of GH in podocyte biology.
- To discuss GH's implications in the pathogenesis of diabetic kidney disease (DKD) and chronic kidney disease (CKD).
Main Methods:
- Literature review focusing on recent studies.
- Analysis of cellular and molecular mechanisms of GH action in the kidney.
Main Results:
- Elevated GH impairs glomerular permselectivity by altering podocyte slit-diaphragm proteins.
- GH promotes podocyte epithelial-mesenchymal transition and reduces podocyte count.
- GH upregulates prosclerotic factors like transforming growth factor-beta (TGF-β) and TGFBIp.
Conclusions:
- Significant progress has been made in understanding GH's role in renal complications of diabetes and acromegaly.
- These findings suggest novel therapeutic targets for preventing and treating diabetic nephropathy.
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