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Updated: Feb 3, 2026
09:24
3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
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Cell-type-specific CD73 expression is an independent prognostic factor in bladder cancer
Maarit K Koivisto1, Minna Tervahartiala1, István Kenessey1
1MediCity Research Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.
Carcinogenesis
|November 6, 2018
Summary
High CD73 enzyme expression in bladder cancer cells predicts a better prognosis. Conversely, low CD73 expression in epithelial and endothelial cells indicates a poorer outcome, highlighting CD73's role as a prognostic biomarker.
Area of Science:
- Immunology
- Oncology
- Biochemistry
Background:
- CD73 is a cell surface enzyme producing adenosine, known for anti-inflammatory and cell migration effects.
- Its role as a prognostic biomarker in bladder carcinoma (BC) requires further investigation.
Purpose of the Study:
- To evaluate CD73 expression as a predictive biomarker for bladder cancer outcomes.
- To correlate CD73 expression with clinical and pathological features in bladder cancer patients.
Main Methods:
- Immunohistochemistry was used to analyze CD73 expression in tumor and stromal cells from 270 bladder cancer patients.
- Statistical analyses included Pearson's, Fischer's tests, Kaplan-Meier, and Cox regression models.
Main Results:
- CD73 expression varied across different cell types within tumors.
- High CD73 expression in cancer cells correlated with better survival in both non-muscle-invasive BC (NMIBC) and muscle-invasive BC (MIBC).
- CD73 negativity in epithelial cells (all BC types) and endothelial cells (MIBC) independently predicted poor outcomes.
Conclusions:
- Unlike in many cancers, high CD73 expression in bladder cancer is associated with a favorable prognosis.
- CD73 expression in cancer cells and stromal fibroblasts serves as a significant prognostic indicator in bladder cancer.
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