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Updated: Feb 3, 2026

Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
Published on: June 7, 2018
Application of In Situ Product Crystallization and Related Techniques in Biocatalytic Processes
Dennis Hülsewede1, Lars-Erik Meyer1, Jan von Langermann1
1Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, A-Einstein-Str. 3A, 18059, Rostock, Germany.
Abstract:
This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.
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