Related Experiment Video
Updated: Feb 3, 2026
07:44
Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
Published on: March 25, 2022
6.8K
Comorbidity of localized scleroderma and primary biliary cholangitis
Gábor Bali1, Anikó Szilvási2, Dóra Inotai2
1Department of Dermatology, Venereology and Dermato-Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Summary
This study investigated the rare association between morphea and primary biliary cholangitis (PBC). Researchers found a potential link, suggesting screening for anti-mitochondrial antibodies (AMA) in certain morphea patients.
Area of Science:
- Dermatology
- Hepatology
- Immunology
Background:
- Morphea frequently co-occurs with autoimmune disorders.
- The association between morphea and primary biliary cholangitis (PBC) is not well-established.
- This study aimed to explore the morphea-PBC link and identify associated risk factors.
Purpose of the Study:
- To investigate the potential association between morphea and primary biliary cholangitis (PBC).
- To identify risk factors for the co-occurrence of these conditions.
Main Methods:
- Screened 91 morphea patients for anti-mitochondrial antibodies (AMA).
- Performed human leucocyte antigen (HLA) genotyping and deep sequencing in AMA-positive patients.
- Assessed for primary biliary cholangitis (PBC) in AMA-positive individuals.
Main Results:
- 6.6% of morphea patients were AMA-positive; 4.39% had PBC.
- AMA-positive patients were older (mean age 69.0 years).
- Common predisposing HLA alleles were identified in some AMA-positive patients, with one patient having alleles for both morphea and PBC.
Conclusions:
- Morphea, AMA positivity, and PBC can coexist, though rarely.
- Shared HLA alleles may contribute to the simultaneous manifestation of these conditions.
- Consider AMA screening for female patients with generalized morphea prior to methotrexate treatment.
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