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Association of hyperuricemia with disease severity in chronic hepatitis C patients

Tyng-Yuan Jang1, Ming-Lun Yeh1,2, Ching-I Huang1

  • 1Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Plos One
|November 6, 2018
PubMed

Insights

Chronic hepatitis C (CHC) patients did not show higher uric acid levels than controls. However, hyperuricemia was linked to factors like BMI and kidney function, and inversely associated with liver disease severity in males.

Area of Science:

  • Hepatology
  • Nephrology
  • Metabolic Disorders

Background:

  • Hepatitis C virus (HCV) infection is linked to metabolic abnormalities and extrahepatic manifestations.
  • The relationship between chronic hepatitis C (CHC) and serum uric acid levels remains under-investigated.

Purpose of the Study:

  • To evaluate serum uric acid levels in patients with chronic hepatitis C (CHC).
  • To identify factors associated with hyperuricemia in CHC patients.

Main Methods:

  • Study included 373 CHC patients undergoing antiviral therapy and 746 controls.
  • Hyperuricemia defined as uric acid > 7 mg/dL (men) or > 6.0 mg/dL (women).
  • Statistical analyses included logistic regression and trend analysis.

Main Results:

  • No significant difference in uric acid levels between CHC patients and controls.
  • Factors associated with hyperuricemia in CHC patients included BMI and eGFR.
  • In male CHC patients, hyperuricemia was associated with BMI and advanced fibrosis (F3-4), showing a decreasing trend of uric acid with fibrosis progression.
  • In female CHC patients, hyperuricemia was associated with eGFR and diabetes.

Conclusions:

  • Hyperuricemia was inversely associated with liver disease severity in male CHC patients.
  • Factors like BMI, eGFR, and diabetes play a role in hyperuricemia among CHC patients.
Abstract

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