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Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasis

Tahereh Zeinali1, Behzad Mansoori2, Ali Mohammadi1

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 6, 2018
PubMed

Insights

Tumor suppressor microRNA-145 (miR-145) is downregulated in cancers, hindering its ability to inhibit tumor metastasis by targeting multiple oncogenes. miR-145 replacement therapy shows promise for cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression involved in cancer development and spread.
  • Reduced expression of the tumor suppressor miR-145 is observed across various solid tumors and blood cancers.
  • The mechanisms behind miR-145 downregulation are complex and not fully understood.

Purpose of the Study:

  • To review the molecular mechanisms regulating miR-145 expression.
  • To explore the role of miR-145 in controlling cancer metastasis.
  • To discuss the potential of miR-145 as a therapeutic agent for cancer metastasis.

Main Methods:

  • Literature review of studies on miR-145 regulation and function in cancer.
  • Analysis of miR-145's targeting of multiple oncogenes involved in metastasis.
  • Discussion of miRNA replacement therapy strategies.

Main Results:

  • miR-145 directly targets numerous oncogenes crucial for tumor cell metastasis, including MUC1, FSCN1, Vimentin, and others.
  • Downregulation of miR-145 contributes to enhanced cancer cell migration and invasion.
  • The multifaceted targeting by miR-145 highlights its significant role in suppressing metastatic potential.

Conclusions:

  • miR-145 acts as a potent suppressor of cancer metastasis through the coordinated regulation of multiple oncogenes.
  • Understanding miR-145's regulatory network is crucial for developing targeted cancer therapies.
  • miRNA replacement therapy using miR-145 presents a promising strategy to combat cancer metastasis.
Keywords:
CancerIinvasionMetastasisTumor-suppressor miRNAmiR-145

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