Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gap Junctions01:27

Gap Junctions

9.6K
The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
9.6K
Gap Junctions01:37

Gap Junctions

57.1K
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
57.1K
Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
P-N junction01:11

P-N junction

1.2K
A p-n junction is formed when p-type and n-type semiconductor materials are joined together. At the interface of the p-n junction, holes from the p-side and electrons from the n-side begin to diffuse into the opposite sides due to the concentration gradient. This diffusion of carriers leads to a region around the junction where there are no free charge carriers, known as the depletion region. The charge density within the depletion region for the n-side and p-side can be described by the...
1.2K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

375
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
375
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

821
Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
821

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A two-stage genome-wide association study to identify novel genetic loci associated with irAEs in lung cancer patients receiving PD-1/PD-L1 inhibitors.

Cancer letters·2025
Same author

ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions.

Molecular biomedicine·2025
Same author

Intestinal fungal signatures and their impact on immune checkpoint inhibitor efficacy: a multi-cohort meta-analysis.

NPJ biofilms and microbiomes·2025
Same author

Gut bacteria and the host synergies promote resveratrol metabolism and induce tolerance in ALD mice.

NPJ biofilms and microbiomes·2025
Same author

Correction: Mao et al. Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats. <i>Int. J. Mol. Sci</i>. 2014, <i>15</i>, 7667-7683.

International journal of molecular sciences·2025
Same author

Analysis of Lifestyle and Genetic Risk Factors in Urban Women in China Who Had Malignant or Suspected Malignant Breast Nodules Identified via Breast Cancer Screening.

Breast care (Basel, Switzerland)·2025

Related Experiment Video

Updated: Feb 3, 2026

Recording Gap Junction Current from Xenopus Oocytes
09:04

Recording Gap Junction Current from Xenopus Oocytes

Published on: January 21, 2022

2.7K

Targeting gap junction in epilepsy: Perspectives and challenges.

Qin Li1, Qiu-Qi Li1, Ji-Ning Jia1

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, Hunan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 6, 2018
PubMed
Summary

Gap junctions (GJs) facilitate cell-to-cell communication crucial for brain activity. Blocking these junctions shows promise in treating epilepsy by disrupting seizure synchronization.

Keywords:
AstrocytesConnexinEpilepsyGap junctionNeurons

More Related Videos

Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy
06:26

Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy

Published on: June 19, 2017

9.3K
An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
09:47

An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay

Published on: February 1, 2019

7.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Recording Gap Junction Current from Xenopus Oocytes
09:04

Recording Gap Junction Current from Xenopus Oocytes

Published on: January 21, 2022

2.7K
Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy
06:26

Analysis of the Gap Junction-dependent Transfer of miRNA with 3D-FRAP Microscopy

Published on: June 19, 2017

9.3K
An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay
09:47

An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay

Published on: February 1, 2019

7.6K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Epilepsy Research

Background:

  • Gap junctions (GJs) are intercellular channels enabling direct ion passage between adjacent cells.
  • Electrical coupling via GJs synchronizes neuronal activity, influencing brain function.
  • GJs are implicated in the generation, synchronization, and maintenance of epileptic seizures.

Purpose of the Study:

  • To review the role of gap junctions in epileptogenesis.
  • To explore the therapeutic potential of targeting GJs for epilepsy treatment.

Main Methods:

  • Literature review of studies investigating gap junctions in epilepsy.
  • Analysis of in vivo and in vitro experimental data on GJ blockers' effects.

Main Results:

  • Gap junction blockers demonstrate significant anti-epileptic effects.
  • Targeting GJs offers a potential novel therapeutic strategy for epilepsy.

Conclusions:

  • Gap junctions play a critical role in the development and progression of epilepsy.
  • Interventions targeting gap junctions represent a promising avenue for novel epilepsy therapies.