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Related Experiment Video

Updated: Feb 3, 2026

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BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice.

Chang Hoon Cho1, Zhongxi Yang1,2, Ki Hyun Yoo1

  • 1Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.

International Neurourology Journal
|November 7, 2018
PubMed
Summary

Reduced levels of the protein budding uninhibited by benzimidazole-related 1 (BubR1) in mice lead to increased anxiety, depression, and memory deficits. This suggests BubR1 is crucial for maintaining normal brain function and may contribute to age-related cognitive decline.

Keywords:
AgingBubR1EmotionHippocampusMemory

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Aging Research

Background:

  • Aging is associated with cognitive decline, but the underlying molecular mechanisms are not fully understood.
  • Budding uninhibited by benzimidazole-related 1 (BubR1), a spindle checkpoint kinase, is implicated in age-related pathologies in various tissues, including the brain.
  • The specific impact of BubR1 on neurobehavioral functions has not been previously investigated.

Purpose of the Study:

  • To investigate the role of BubR1 in regulating behavioral functions.
  • To explore the neurobiological functions of BubR1 in vivo.

Main Methods:

  • Utilized transgenic mice with hypomorphic BubR1 alleles (BubR1H/H) and mice with targeted BubR1 knockdown in the adult dentate gyrus.
  • Assessed anxiety-like behavior using the elevated plus maze and light-dark test.
  • Evaluated depression-like behavior with the tail-suspension and forced-swim tests.
  • Tested memory function through novel object recognition.

Main Results:

  • BubR1H/H mice exhibited increased anxiety, depression-like behavior, and impaired memory compared to wild-type littermates.
  • Knockdown of BubR1 in the adult dentate gyrus replicated these behavioral deficits, including increased anxiety, depression-like behavior, and memory impairment.
  • These findings indicate a direct link between BubR1 levels and specific behavioral outcomes.

Conclusions:

  • BubR1 is essential for maintaining normal affective and memory-related behavioral functions.
  • A decline in BubR1 levels with age may significantly contribute to age-related hippocampal dysfunction.
  • This study highlights BubR1 as a potential therapeutic target for age-related cognitive and affective disorders.