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Related Experiment Videos

Human corticotroph cell adenomas.

F Robert, J Hardy

    Seminars in Diagnostic Pathology
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Pituitary corticotroph adenomas, often microadenomas, in Cushing's disease and Nelson's syndrome show characteristic ultrastructural microfilaments. These tumors, regardless of clinical presentation, share similar microscopic and immunocytological features.

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    Area of Science:

    • Endocrinology
    • Pathology
    • Oncology

    Background:

    • Cushing's disease and Nelson's syndrome are conditions associated with pituitary corticotroph adenomas.
    • Understanding the characteristics of these adenomas is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To characterize pituitary corticotroph adenomas from patients with Cushing's disease, Nelson's syndrome, and eucorticoid patients.
    • To investigate the microscopic, immunocytological, and ultrastructural features of these tumors.

    Main Methods:

    • Light microscopy, immunoperoxidase staining, and electron microscopy were employed.
    • Sixty-one pituitary corticotroph adenomas were analyzed.
    • Immunostaining included antisera to adrenocorticotrophic hormone (ACTH), beta-lipotropic hormones (beta-LPH), and beta-endorphin.

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    Main Results:

    • Seventy-nine percent of all tumors were microadenomas.
    • The most consistent ultrastructural finding was perinuclear microfilaments.
    • Adenoma cells stained positively for ACTH, beta-LPH, and beta-endorphin.
    • Silent corticotroph adenomas showed no distinct differences in features.

    Conclusions:

    • Pituitary corticotroph adenomas exhibit characteristic microscopic and ultrastructural features, including perinuclear microfilaments.
    • These features are consistent across different clinical presentations, including Cushing's disease, Nelson's syndrome, and silent adenomas.
    • Further research into these ultrastructural findings may offer insights into adenoma pathogenesis.