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Dedicated breast PET value to evaluate BI-RADS 4 breast lesions
L Graña-López1, M Herranz2, I Domínguez-Prado2
1Radiology Department, Hospital Lucus Augusti Lugo, Ulises Romero 1, Lugo, 27003, Spain.
European Journal of Radiology
|November 7, 2018
Summary
Dedicated breast PET (dbPET) shows limited diagnostic value for BI-RADS 4 lesions, with a high false-negative rate for in situ carcinomas. While it detected all invasive carcinomas within its field of view, it is not recommended for routine diagnosis.
Area of Science:
- Oncology
- Radiology
- Nuclear Medicine
Background:
- Breast Imaging Reporting And Data Systems (BI-RADS) category 4 lesions require further investigation to rule out malignancy.
- Dedicated breast PET (dbPET) offers high resolution for breast imaging, potentially improving lesion detection.
Purpose of the Study:
- To assess the diagnostic performance of dbPET in identifying malignant BI-RADS 4 breast lesions detected by mammography or ultrasound.
Main Methods:
- Prospective study of 50 women with 60 BI-RADS 4 lesions.
- dbPET and MRI imaging were performed before biopsy.
- Image fusion of dbPET and MRI was used for lesion localization.
- Sensitivity and specificity of dbPET were calculated and compared to histopathology.
Main Results:
- Histopathology confirmed 18 malignant and 42 benign lesions.
- dbPET demonstrated 50% sensitivity and 76% specificity.
- A high false-negative rate (85.7%) was observed for in situ carcinomas.
- All invasive carcinomas within the field of view were detected.
Conclusions:
- dbPET is not recommended for diagnosing malignancy in BI-RADS 4 lesions due to its limitations with in situ carcinomas.
- dbPET accurately detected invasive carcinomas within its field of view, suggesting potential utility in specific scenarios.
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