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Cystathione β-Synthase Is Increased in Thyroid Malignancies.
Elba A Turbat-Herrera1, Matthew J Kilpatrick1, Jie Chen1
1Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
Anticancer Research
|November 7, 2018
Summary
Cystathione β-synthase (CBS), an enzyme producing hydrogen sulfide (H2S), is elevated in thyroid cancers. This finding suggests CBS and NAMPT may help distinguish benign from malignant thyroid tumors.
Area of Science:
- Biochemistry
- Oncology
- Molecular Biology
Background:
- Cystathione β-synthase (CBS) is crucial in the trans-sulfuration pathway, producing hydrogen sulfide (H2S).
- Elevated CBS protein expression is linked to advanced tumor stages, metastasis, and chemoresistance in various human cancers.
Purpose of the Study:
- To investigate the role of CBS in thyroid malignancies.
- To evaluate CBS expression in different types of thyroid tumors.
- To explore the potential diagnostic utility of CBS and NAMPT in thyroid cancer.
Main Methods:
- Tissue microarrays were utilized to analyze CBS expression.
- Expression levels were compared across benign thyroid tissue, oncocytomas, follicular adenomas, and follicular, papillary, anaplastic, and medullary thyroid carcinomas.
- Nicotinamide phosphoribosyltransferase (NAMPT) expression was also analyzed.
Main Results:
- CBS expression was significantly increased in all examined thyroid carcinoma types compared to benign thyroid tissue.
- No significant increase in CBS expression was observed in thyroid follicular adenomas or oncocytomas.
- Similar expression patterns were noted for NAMPT when comparing thyroid adenomas and follicular carcinomas.
Conclusions:
- This study demonstrates, for the first time, the involvement of an H2S-synthesizing enzyme, CBS, in thyroid malignancies.
- CBS and NAMPT immunohistochemistry may serve as valuable tools for differentiating between follicular adenomas and follicular carcinomas.
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