Author Correction: Public resources aid diabetes gene discovery

Area of Science:

• Genetics
• Metabolic Diseases
• Human Health

Background:

• Type 2 Diabetes (T2D) is a complex metabolic disease with a significant genetic component.
• Previous large-scale genome-wide association studies (GWAS) have identified numerous genetic loci associated with T2D risk.
• Understanding the full genetic architecture of T2D is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

• To correct a misstatement in a previously published article regarding the proportion of T2D genetic risk explained by identified variants.
• To accurately reflect the current understanding of the genetic contribution to T2D susceptibility.

Main Methods:

• This is a correction notice, not a primary research study.
• The correction involves revising specific sentences within the 'Remaining challenges' section of the original publication.
• The correction pertains to the interpretation of genetic heritability explained by common, low-frequency, and rare variants.

Main Results:

• The corrected text accurately states that 'a proportion' of the genetic component of T2D risk is explained by identified variants, rather than a specific figure of approximately 18%.
• The correction emphasizes that a relatively small proportion of T2D heritability is explained by low-frequency or rare variants, suggesting more variants remain to be discovered.
• The HTML and PDF versions of the paper have been updated to reflect this correction.

Conclusions:

• Accurate reporting of genetic findings is essential for scientific progress in understanding complex diseases like T2D.
• Further research with larger sample sizes is needed to fully characterize the genetic variants contributing to T2D.
• This correction ensures the scientific community has precise information regarding T2D genetic risk factors.