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Gemcitabine-induced skin necrosis.

Maria Monica Haydock1, Saroj Sigdel2, Toni Pacioles2

  • 1Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK.

SAGE Open Medical Case Reports
|November 7, 2018
PubMed
Summary

Gemcitabine, a chemotherapy drug, can cause skin reactions. This report details a rare case of skin necrosis in a patient treated with gemcitabine for pancreatic cancer.

Keywords:
Oncologyadverse skin reactionschemotherapygastroenterology/hepatologygemcitabinepancreatic cancerpharmacoepidemiology/drug safety

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Area of Science:

  • Oncology
  • Dermatology

Background:

  • Gemcitabine is a widely used chemotherapy agent for various cancers.
  • Cutaneous adverse reactions are known side effects of gemcitabine treatment.
  • Rash is the most frequent dermatologic manifestation, but other reactions like bullous dermatosis and palmar-plantar erythrodysesthesia have been documented.

Observation:

  • A 74-year-old male patient with pancreatic adenocarcinoma underwent a Whipple procedure.
  • The patient received six cycles of gemcitabine monotherapy.
  • Two weeks after completing treatment, the patient developed skin necrosis on the lower leg.

Findings:

  • Skin necrosis is an exceptionally rare adverse event associated with gemcitabine.
  • This case represents one of the few documented instances of gemcitabine-induced skin necrosis in the medical literature.
  • The patient's presentation highlights a severe, albeit infrequent, cutaneous reaction to gemcitabine.

Implications:

  • Awareness of rare gemcitabine-associated skin necrosis is crucial for oncologists and dermatologists.
  • Prompt recognition and management of severe cutaneous reactions are essential for patient safety.
  • Further investigation into the mechanisms underlying gemcitabine-induced skin necrosis may inform preventative strategies.