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Updated: Feb 3, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
Published on: December 19, 2018
Estrogen Receptors alpha and beta in Ovarian Cancer: Expression Level and Prognosis
T A Bogush1, A A Basharina2,3, E A Bogush2
1Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, 115478, Russia. tatbogush@mail.ru.
Abstract:
The quantitative immunofluorescence assay of serous ovarian cancer tissue for the expression of estrogen receptors (ERα and ERβ) revealed a higher expression level of ERβ in comparison with ERα in all surgical tumor samples investigated. Significant differences in the expression level of the markers were detected "from tumor to tumor." A high expression level of both ERα (≥ 25%) and ERβ (≥ 44%) in the tumor predicts a significantly longer progression-free survival time (p < 0.01) in the patients after the first line of platinum and taxane-based adjuvant chemotherapy.
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