Related Experiment Video
Updated: Feb 3, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Recent progress in the emerging role of exosome in hepatocellular carcinoma
Mubalake Abudoureyimu1, Hao Zhou2, Yingru Zhi1
1Department of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
Abstract:
Exosomes are small membrane vesicles 50-150 nm in diameter released by a variety of cells, which contain miRNAs, mRNAs and proteins with the potential to regulate signalling pathways in recipient cells. Exosomes deliver nucleic acids and proteins to participate in orchestrating cell-cell communication and microenvironment modulation. In this review, we summarize recent progress in our understanding of the role of exosomes in hepatocellular carcinoma (HCC). This review focuses on recent studies on HCC exosomes, considering biogenesis, cargo and their effects on the development and progression of HCC, including chemoresistance, epithelial-mesenchymal transition, angiogenesis, metastasis and immune response. Finally, we discuss the clinical application of exosomes as a therapeutic agent for HCC.
Related Concept Videos
Emerging Adulthood
Introduction Cardiac Emergencies
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Applications of GIS: Disaster Management and Emergency Response
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

