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Updated: Feb 3, 2026
06:52
Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
Published on: April 30, 2019
18.5K
A case of bleomycin-induced lung toxicity
Cuneyt Tetikkurt1, Deniz Ongel, Seza Tetikkurt
1Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department. tetikkurt@gmail.com.
Summary
This case highlights fatal bleomycin toxicity causing respiratory insufficiency in a Hodgkin lymphoma patient. Early recognition and management of bleomycin-induced pulmonary complications are crucial.
Area of Science:
- Pulmonology
- Oncology
- Pharmacology
Background:
- Bleomycin is a chemotherapy agent used for Hodgkin lymphoma.
- Bleomycin can cause significant pulmonary toxicity, affecting up to 50% of patients.
- Comorbid conditions may increase the risk of severe bleomycin-induced lung injury.
Observation:
- A 64-year-old female with a history of Hodgkin lymphoma presented with progressive dyspnea and cough.
- Imaging revealed cystic lesions, emphysema, ground glass, and reticular opacities.
- The patient's respiratory status worsened despite oxygen therapy and BiPAP support.
Findings:
- The patient was diagnosed with respiratory insufficiency secondary to bleomycin toxicity.
- Treatment included methylprednisolone and bilevel positive airway pressure (BiPAP).
- Despite interventions, the patient deceased due to complications of bleomycin toxicity.
Implications:
- This case underscores the severe pulmonary risks associated with bleomycin chemotherapy.
- Awareness of bleomycin-induced pulmonary complications is vital for clinicians, especially in patients with comorbidities.
- Careful monitoring and prompt management are essential to mitigate potentially fatal outcomes of bleomycin toxicity.
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