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Is the New Infant Jarvik 2015 Suitable for Patients<8 kg? In Vitro Study Using a Hybrid Simulator.

Arianna Di Molfetta1, Krzysztof Zielinski2, Gianfranco Ferrari2

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The Infant Jarvik 2015 left ventricular assist device (LVAD) shows feasibility for pediatric patients under 8 kg. Its stability and hemodynamic support in simulations suggest suitability for this vulnerable patient group.

Keywords:
Hybrid modelInfant Jarvik 2015Lumped parameter modelsPediatricVentricular assist device

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Area of Science:

  • Biomedical Engineering
  • Pediatric Cardiology
  • Medical Device Technology

Background:

  • Pediatric heart failure necessitates advanced mechanical circulatory support.
  • Left ventricular assist devices (LVADs) are crucial for improving outcomes in pediatric patients.
  • The Infant Jarvik 2015 is a novel LVAD designed for smaller patients.

Purpose of the Study:

  • To evaluate the feasibility and performance of the Infant Jarvik 2015 LVAD in pediatric patients weighing less than 8 kg.
  • To assess the device's stability and hemodynamic impact across a range of simulated patient weights and circulatory conditions.

Main Methods:

  • A hybrid simulator of the cardiovascular system was used to model pediatric patients from 2-7 kg.
  • The Infant Jarvik 2015's sensitivity to parameters like peripheral resistance, ventricular elastance, and heart rate was tested.
  • Pump speed was varied (10,000-18,000 rpm) to analyze device output and patient hemodynamics.

Main Results:

  • The LVAD demonstrated stability across various simulated hemodynamic conditions, with low frequencies of suction and backflow.
  • Device operation led to predictable changes in atrial and ventricular pressures and volumes.
  • Adequate patient hemodynamics were maintained, with the LVAD capable of supporting total cardiac output.

Conclusions:

  • The Infant Jarvik 2015 shows promise for implantation in pediatric patients weighing less than 8 kg.
  • The device's stability and ability to maintain adequate hemodynamics in simulated scenarios support its potential clinical application.
  • Further investigation is warranted to confirm these findings in clinical settings.