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Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
A new oleanane triterpene from the leaves of Ficus hirta
Dao Duc Thien1, Tran Duc Dai2,3, Nguyen Hoang Sa4
1Natural Products Research Laboratory, Institute of Chemistry, Vietnam Academy of Science and Technology , Cau Giay , Ha Noi , Vietnam.
Abstract:
Repeated column chromatography of the n-hexane extract of Ficus hirta leaves (Moraceae) led to isolation of a new oleanane triterpene, 3β-hydroxy-11-oxo-olean-12-enyl-3-stearate (1) in addition to three known compounds, taraxerol (2), 3β-acetoxy-11α-methoxy-12-ursene (3) and 3β-acetoxy-11α-hydroxy-12-ursene (4). Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literatures.
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Leaving Groups
In general, in a nucleophilic substitution reaction, a nucleophile displaces a functional group, called the leaving group, from the substrate to give a substituted product. A leaving group departs the substrate molecule through heterolytic cleavage, taking the pair of electrons with it to become a relatively stable weak base in the form of an anion or a neutral molecule.
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