Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Different localization of thrombomodulin].

M C Boffa, B Burke, C Haudenschild

Annales De Biologie Clinique

|January 1, 1987

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retraction: Minimal skin dose increase in longitudinal rotating biplanar linac-MR systems: examination of radiation energy and flattening filter design (2016<i>Phys. Med. Biol.</i>61 3527).

Physics in medicine and biology·2025

Same author

Perinatal and neonatal outcomes of high-risk asymptomatic women from a specialist preterm birth surveillance clinic.

European journal of obstetrics, gynecology, and reproductive biology·2024

Same author

Performance of QUiPP App v.2 tool for prediction of preterm birth in asymptomatic high-risk women attending preterm specialist clinic: external validation study.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024

Same author

A cross-sectional survey of women's views and preferences for preterm birth screening and treatment.

European journal of obstetrics, gynecology, and reproductive biology·2023

Same author

Is it Time to Bin Next of Kin?

Irish medical journal·2022

Same author

Proton beam behavior in a parallel configured MRI-proton therapy hybrid: Effects of time-varying gradient magnetic fields.

Medical physics·2018

Thrombomodulin (TM) is found on the surface of all blood vessels and serosal linings in rabbits. This endothelial protein

Area of Science:

Endothelial biology
Immunohistochemistry
Protein distribution studies

Context:

Thrombomodulin (TM) is a key component of the protein C anticoagulant pathway.
Understanding TM distribution is crucial for its role in vascular health.
Previous studies have not fully elucidated the systemic distribution of TM.

Purpose:

To investigate the tissue distribution of thrombomodulin (TM) antigen in rabbits.
To characterize the cellular localization of TM using immunohistochemistry.

Summary:

Thrombomodulin (TM) antigen was detected on the endothelial surfaces of all blood vessels (capillaries, arteries, veins) in rabbits.
TM was also found on serosal surfaces (peritoneum, pericardium, pleura), synovial membranes, and the arachnoid, but not on pia or dura mater.

Related Experiment Videos

The antigen's presence was specific to endothelial and certain mesothelial surfaces, with absence in connective tissue, muscle, bone, cartilage, nerve tissue, and parenchyma.

Impact:

Reveals the widespread presence of TM on endothelial and serosal surfaces.
Suggests potential mobility of TM, indicating production and function sites may differ.
Provides a comprehensive map of TM distribution relevant to anticoagulant and inflammatory processes.