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Updated: Feb 3, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

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Prognostic Value of Vascular Calcifications and Regional Fat Depots Derived From Conventional Chest Computed

Gastón A Rodríguez-Granillo1, Exequiel Reynoso1, Carlos Capuñay1

  • 1Department of Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.

Journal of Thoracic Imaging
|November 7, 2018
PubMed

Insights

Pericardial fat volume and coronary artery calcification are significant predictors of mortality in patients undergoing chest CT. Higher levels of both indicate increased risk and are associated with worsening survival rates.

Area of Science:

  • Radiology
  • Cardiovascular Imaging
  • Metabolic Health

Background:

  • Vascular calcifications and regional fat depots are known prognostic indicators.
  • Previous studies often assessed these factors separately using gated CT.
  • Conventional non-gated chest CT offers a potential for integrated assessment.

Purpose of the Study:

  • To investigate the combined prognostic value of vascular calcifications and adipose tissue depots.
  • To explore their interplay when assessed during conventional non-gated chest CT examinations.

Main Methods:

  • 1250 patients (35-74 years) undergoing clinically indicated chest CT were enrolled.
  • Coronary artery calcification (CAC) score, aortic and valve calcification were measured.
  • Pericardial fat volume (PFV), hepatic fat, and abdominal subcutaneous adipose tissue were quantified.

Main Results:

  • Higher PFV correlated with older age, male sex, and increased abdominal/hepatic fat.
  • Elevated PFV and higher CAC segment-involvement score (CACSIS > 5) were independent predictors of all-cause mortality.
  • Multivariable analysis identified age, PFV upper tertile, and CACSIS > 5 as significant risk factors.

Conclusions:

  • Pericardial fat volume and coronary calcification are high-risk markers in patients undergoing conventional chest CT.
  • These factors are associated with significantly worsening survival.
  • Non-gated chest CT can effectively assess these combined risk factors for improved prognostic evaluation.
Abstract

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