Related Experiment Video

Updated: Feb 3, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

725

Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain

Michelle A Kominiarek1, Marcela C Smid, Lisa Mele

  • 1Departments of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, University of Utah Health Sciences Center, Salt Lake City, Utah, University of Texas-Southwestern, Dallas, Texas, Wayne State University, Detroit, Michigan, Columbia University, New York, New York, University of North Carolina, Chapel Hill, North Carolina, University of Texas Medical Branch, Galveston, Texas, University of Alabama at Birmingham, Birmingham, Alabama, Brown University, Providence, Rhode Island, University of Texas-Houston, Houston, Texas, The Ohio State University, Columbus, Ohio, Case Western Reserve University, Cleveland, Ohio, Oregon Health Sciences University, Portland, Oregon, and University of Pittsburgh, Pittsburgh, Pennsylvania; the George Washington University Biostatistics Coordinating Center, Washington, DC; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, Maryland.

Obstetrics and Gynecology
|November 7, 2018
PubMed

Insights

Maternal pre-pregnancy body mass index (BMI) and gestational weight gain did not impact child neurodevelopmental outcomes in women with thyroid conditions. Adjusted analyses confirmed no significant associations, highlighting the importance of considering confounding factors.

Area of Science:

  • Maternal-fetal medicine
  • Pediatric neurodevelopment
  • Endocrinology

Background:

  • Maternal pre-pregnancy body mass index (BMI) and gestational weight gain are potential factors influencing child neurodevelopmental outcomes.
  • Thyroid dysfunction during pregnancy, such as hypothyroxinemia or subclinical hypothyroidism, may affect maternal health and fetal development.
  • Understanding these associations is crucial for optimizing prenatal care and improving long-term child health.

Purpose of the Study:

  • To investigate the relationship between pre-pregnancy body mass index (BMI) and gestational weight gain with neurodevelopmental outcomes in children.
  • To analyze these associations in pregnant women with hypothyroxinemia or subclinical hypothyroidism.

Main Methods:

  • Secondary analysis of data from two randomized, double-blind, placebo-controlled thyroxine replacement trials.
  • Categorization of pre-pregnancy BMI (normal, overweight, obese) and gestational weight gain (inadequate, adequate, excessive).
  • Assessment of child neurodevelopment using Wechsler Preschool and Primary Scale of Intelligence and Differential Ability Scales-II at ages 5 and 3 years, respectively, with adjusted regression analyses.

Main Results:

  • Maternal pre-pregnancy BMI and gestational weight gain showed no significant association with child neurodevelopmental outcomes in adjusted analyses.
  • Unadjusted analyses indicated lower cognitive scores in children of obese and overweight mothers, but these differences were accounted for by factors like race-ethnicity and education.
  • Adequacy of early, late, or total gestational weight gain was not associated with neurodevelopmental outcomes.

Conclusions:

  • In pregnant women with hypothyroxinemia or subclinical hypothyroidism, neither pre-pregnancy BMI nor gestational weight gain was linked to child neurodevelopmental outcomes after adjustment for confounding variables.
  • These findings suggest that other factors may play a more significant role in determining neurodevelopmental trajectories in this population.
Abstract

More Related Videos

Neurodevelopmental Reflex Testing in Neonatal Rat Pups09:35

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

21.1K
Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure07:56

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure

Published on: September 19, 2019

10.8K

Related Concept Videos

Mass and Weight01:19

Mass and Weight

Mass and weight are often used interchangeably in everyday conversation. For example,  medical records often show our weight in kilograms, but never in the correct units of newtons. In physics, however, there is an important distinction. Weight is the pull of the Earth on an object. It depends on the distance from the center of the Earth. Weight dramatically varies if we leave the Earth's surface, unlike mass, which does not vary with location. On the Moon, for example, the...
15.3K
Gain01:15

Gain

Gain and phase shift are properties of linear circuits that describe the effect a circuit has on a sinusoidal input voltage or current. The circuit's behavior that contains reactive elements will depend on the frequency of the input sinusoid. As a result, it is observed that the gain and phase shift will all be frequency functions.
Gain:
Suppose Vin is the input and Vout is the output signal to a circuit.
410
Reduced Mass Coordinates: Isolated Two-body Problem01:12

Reduced Mass Coordinates: Isolated Two-body Problem

In classical mechanics, the two-body problem is one of the fundamental problems describing the motion of two interacting bodies under gravity or any other central force. When considering the motion of two bodies, one of the most important concepts is the reduced mass coordinates, a quantity that allows the two-body problem to be solved like a single-body problem. In these circumstances, it is assumed that a single body with reduced mass revolves around another body fixed in a position with an...
2.4K
Weighted Mean00:57

Weighted Mean

While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
6.3K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K