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Related Concept Videos

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Friendship formation is a dynamic process shaped by psychological, cultural, and social factors. Friendships play a crucial role in emotional well-being, social development, and personal identity from childhood to adulthood.Childhood and Early FriendshipsFriendships in childhood often arise due to shared environments, such as school or neighborhood interactions. At this stage, proximity and common interests serve as the primary basis for connection. As children grow, their friendships evolve...
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Related Experiment Video

Updated: Feb 3, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Preeclampsia: A close look at renal dysfunction.

Hakimeh Moghaddas Sani1, Sepideh Zununi Vahed1, Mohammadreza Ardalan1

  • 1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 7, 2018
PubMed
Summary

Preeclampsia (PE) involves diverging maternal, fetal, and placental interests due to increased antiangiogenic factors from a hypoxic placenta. This condition, marked by hypertension and proteinuria, impairs kidney function via the vascular endothelial growth factor (VEGF) pathway.

Keywords:
Glomerular endotheliosisHypertensionPlacentaPodocytopathyProteinuriaRenal dysfunction

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Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Pathophysiology

Background:

  • Preeclampsia (PE) is a pregnancy complication where maternal, fetal, and placental physiological interests diverge.
  • It is characterized by new-onset hypertension and proteinuria after 20 weeks of gestation.
  • PE is linked to increased antiangiogenic factors from a hypoxic placenta, notably soluble fms-like tyrosine kinase 1 (sFlt-1).

Purpose of the Study:

  • To review the biochemical, genetic, and immunological factors in preeclampsia initiation.
  • To explore the relationship between kidney dysfunction and preeclampsia.
  • To elucidate the pathological mechanisms of kidney involvement in PE, focusing on the VEGF signaling pathway.

Main Methods:

  • Literature review of preeclampsia pathophysiology.
  • Analysis of the role of antiangiogenic factors, specifically sFlt-1.
  • Examination of the vascular endothelial growth factor (VEGF) and its receptor signaling in kidney damage.

Main Results:

  • Hypoxic placenta in PE increases sFlt-1, which blocks VEGF binding, damaging the glomerular filtration barrier.
  • Kidney involvement in PE features glomerular endotheliosis and thrombotic microangiopathy (TMA), leading to clotting and vessel occlusion.
  • While symptoms often improve post-delivery, permanent kidney damage can persist and worsen.

Conclusions:

  • The imbalanced VEGF-VEGF receptor signaling pathway is central to the kidney pathology in preeclampsia.
  • Understanding these mechanisms is crucial for managing PE and its long-term renal consequences.
  • Further research into PE's biochemical, genetic, and immunological underpinnings is warranted.