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Mayur Katariya1, Dwayne Chung Kim Chung1, Tristan Minifie1

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Summary
This summary is machine-generated.

This study adapted drone propellers for en-route sample centrifugation, improving pre-analytical sample quality. The novel method successfully separated milk and human blood components during flight.

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Area of Science:

  • Biomedical Engineering
  • Aerospace Engineering
  • Analytical Chemistry

Background:

  • The pre-analytical phase of sample handling is critical for diagnostic accuracy.
  • Current limitations in remote or field-based sample processing hinder timely analysis.
  • On-site sample preparation can significantly improve sample integrity and reduce turnaround times.

Purpose of the Study:

  • To develop and demonstrate a novel method for en-route sample centrifugation using adapted drone technology.
  • To assess the efficacy of drone-based centrifugation in separating biological and non-biological fluid components.
  • To enhance the pre-analytical phase by enabling sample processing during transport.

Main Methods:

  • Modification of quadcopter propellers to generate centrifugal forces on capillary tubes containing samples.
  • Testing the system with non-homogenized milk samples to assess separation capabilities.
  • Validation using human whole blood samples to evaluate component separation (plasma, buffy coat, red blood cells).

Main Results:

  • Successful separation of non-homogenized milk into cream and skim milk portions was achieved.
  • Human whole blood was effectively separated into plasma, buffy coat, and red blood cell components.
  • The adapted drone propellers demonstrated the capacity to apply sufficient centrifugal force for sample fractionation.

Conclusions:

  • En-route centrifugation using adapted drone propellers is a feasible method to improve pre-analytical sample quality.
  • This innovative approach offers potential for field-based diagnostics and remote sample processing.
  • The technology paves the way for enhanced sample handling in challenging or mobile environments.