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Updated: Feb 3, 2026
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Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation
Published on: November 26, 2011
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Amide Activation in Ground and Excited States
Ervin Kovács1, Balázs Rózsa2, Attila Csomos3
1Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest H-1117, Hungary. kovacs.ervin@ttk.mta.hu.
Molecules (Basel, Switzerland)
|November 8, 2018
Summary
New concepts of amidicity and carbonylicity offer a simple, intuitive way to predict amide stability and reactivity. These quasi-thermodynamic data aid chemists in understanding chemical processes and biological mechanisms.
Area of Science:
- Organic Chemistry
- Computational Chemistry
- Biochemistry
Background:
- Amide bonds are fundamental in chemistry and biology.
- Existing models may not fully capture the nuances of amide stability and reactivity.
Purpose of the Study:
- To introduce and validate the concepts of amidicity and carbonylicity for amide bond analysis.
- To provide a practical tool for predicting amide stability and reactivity.
Main Methods:
- Development of two new concepts: amidicity and carbonylicity.
- Application of simple quantum-chemical calculations.
- Demonstration through various chemical reactions and biological processes.
Main Results:
- Amidicity and carbonylicity provide intuitive, quasi-thermodynamic data.
- The concepts accurately describe amide bond strength and activation.
- Successful application to transamidation, acyl transfer, amide reductions, protein splicing, and drug mechanisms.
Conclusions:
- Amidicity and carbonylicity offer a simplified, practical approach to understanding amide chemistry.
- These concepts enhance the prediction of chemical reaction outcomes and biological interactions.
- The framework is applicable to diverse areas, including photo-activation studies.
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