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Updated: Feb 3, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
Published on: October 20, 2018
Large-Area and High-Throughput PDMS Microfluidic Chip Fabrication Assisted by Vacuum Airbag Laminator
Shuting Xie1, Jun Wu2, Biao Tang3
1Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics & Joint International Research Laboratory of Optical Information of the Chinese Ministry of Education, South China Normal University, Guangzhou 510006, China. stxie@m.scnu.edu.cn.
Abstract:
One of the key fabrication steps of large-area microfluidic devices is the flexible-to-hard sheet alignment and pre-bonding. In this work, the vacuum airbag laminator (VAL) which is commonly used for liquid crystal display (LCD) production has been applied for large-area microfluidic device fabrication. A straightforward, efficient, and low-cost method has been achieved for 400 × 500 mm² microfluidic device fabrication. VAL provides the advantages of precise alignment and lamination without bubbles. Thermal treatment has been applied to achieve strong PDMS⁻glass and PDMS⁻PDMS bonding with maximum breakup pressure of 739 kPa, which is comparable to interference-assisted thermal bonding method. The fabricated 152 × 152 mm² microfluidic chip has been successfully applied for droplet generation and splitting.
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