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Updated: Feb 3, 2026
08:56
Development of New Therapeutic Applications Using Microfluidics
Published on: October 1, 2007
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Biomaterials Meet Microfluidics: From Synthesis Technologies to Biological Applications
Jingyun Ma1,2, Yachen Wang3,4, Jing Liu5,6
1Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. majingyun@dmu.edu.cn.
Micromachines
|November 8, 2018
Summary
Microfluidic technology enables superior functional biomaterial synthesis with controllable properties. This review covers microfluidic synthesis methods and biomedical applications for 0D, 1D, 2D, and 3D biomaterials.
Area of Science:
- Biomaterials Engineering
- Microfluidics
- Nanotechnology
Background:
- Microfluidics offers unique advantages like laminar flow, high surface-to-volume ratio, and enhanced heat/mass transfer.
- These characteristics facilitate large-scale integration and flexible manipulation, making microfluidic technology crucial for functional biomaterial synthesis.
- Biomaterials synthesized using microfluidics exhibit superior properties and performance compared to conventional methods due to controlled morphology and composition.
Purpose of the Study:
- To highlight microfluidic synthesis technologies for functional biomaterials.
- To review the biomedical applications of microfluidic-engineered biomaterials.
- To classify microfluidic-based biomaterials based on dimensionality (0D, 1D, 2D, 3D).
Main Methods:
- Classification of microfluidic-based biomaterials into four categories: 0D (particulate), 1D (fibrous), 2D (sheet), and 3D (constructs).
- Focus on the synthesis and applications of micro/nano-particles and micro/nano-fibers.
- Comprehensive evaluation of microfluidic biomaterials and their applications.
Main Results:
- Microfluidic synthesis allows precise control over biomaterial morphology and composition.
- Engineered biomaterials demonstrate significant advantages in biomedicine, biosensing, and tissue engineering.
- A systematic classification framework for microfluidic biomaterials is presented.
Conclusions:
- Microfluidic technology is a powerful platform for advanced functional biomaterial synthesis.
- The controllable nature of microfluidic synthesis leads to superior biomaterial performance.
- This review provides a comprehensive overview of microfluidic biomaterials and their diverse biomedical applications.
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