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Updated: Feb 3, 2026
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Progress in research on the role of circular RNAs in lung cancer
Yang Chen1, Shuzhen Wei2, Xiyong Wang1
1Medical School of Southeast University, Nanjing, China.
Background:
Circular RNA (circRNA), as a covalently closed circular RNA molecule, is widely present, which is recognized as a competing endogenous RNA. A large number of differentially expressed circRNAs have been identified and are recognized as potential biomarkers for the diagnosis of tumors.
Main Body:
CircRNAs play an important role in the regulation of cell signaling pathways. The main biological functions of circRNAs include acting as miRNA sponges, regulating the transcription of the parental genes, and acting as adapters to regulate the interactions between proteins and encoding proteins. Compared with normal tissues, there are differentially expressed circRNAs in lung cancer tissue, and the expression levels of circRNAs are correlated with clinicopathological features of lung cancer. Their roles in pathway regulation are described, and the diagnostic and prognostic values are further evaluated.
Conclusion:
In lung cancer, circRNAs participate in the proliferation, migration, and invasion, acting as a competitive endogenous RNA. Differentially expressed circRNAs may serve as non-invasive diagnostic markers for lung cancers. Further investigation of the roles of circRNAs in the pathogenesis and regulatory pathways is conducive to the development of novel approaches for the diagnosis and accurate treatment of lung cancers.
Insights
Circular RNAs (circRNAs) are key regulators in lung cancer, influencing cell processes and acting as competing endogenous RNAs. Differentially expressed circRNAs show promise as non-invasive biomarkers for lung cancer diagnosis and treatment.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Circular RNAs (circRNAs) are covalently closed RNA molecules functioning as competing endogenous RNAs.
- Numerous differentially expressed circRNAs are identified as potential tumor diagnostic biomarkers.
- circRNAs are implicated in regulating cell signaling pathways, including miRNA sponging and gene transcription.
Purpose of the Study:
- To investigate the role of circRNAs in lung cancer.
- To evaluate the diagnostic and prognostic value of circRNAs in lung cancer.
- To explore circRNAs' involvement in pathway regulation within lung cancer.
Main Methods:
- Analysis of differentially expressed circRNAs in lung cancer tissues compared to normal tissues.
- Evaluation of the correlation between circRNA expression levels and clinicopathological features.
- Assessment of circRNAs' functions in cell proliferation, migration, and invasion.
Main Results:
- CircRNAs are differentially expressed in lung cancer tissues.
- CircRNA expression levels correlate with lung cancer clinicopathological features.
- circRNAs participate in lung cancer cell proliferation, migration, and invasion.
Conclusions:
- circRNAs act as competing endogenous RNAs in lung cancer, affecting key cellular processes.
- Differentially expressed circRNAs represent potential non-invasive diagnostic markers for lung cancer.
- Further research into circRNAs' roles can lead to novel diagnostic and therapeutic strategies for lung cancer.
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