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Updated: Feb 3, 2026

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
Published on: June 24, 2019
[Critically ill patient isolation: risk or protection?]
I Gutiérrez-Cía1, C Aibar-Remón2, B Obón-Azuara3
1Hospital Clínico Universitario, Zaragoza, España; Instituto de Investigación Sanitaria Aragón, Zaragoza, España.
Implementing isolation precautions in intensive care units (ICUs) does not increase patient safety incidents (PSIs). This study found that PSIs are frequent but preventable, emphasizing the need for a strong patient safety culture.
Area of Science:
- Critical Care Medicine
- Infectious Disease Control
- Patient Safety
Background:
- Isolation precautions are crucial for preventing the spread of multi-resistant microorganisms (MMR).
- However, their complex implementation may pose risks to patient safety.
- This study investigates the relationship between isolation precautions and patient safety incidents (PSIs) in critically ill patients.
Purpose of the Study:
- To determine if isolation precautions increase the risk of PSIs in critically ill patients.
- To analyze the types, severity, and preventability of PSIs during isolation periods.
Main Methods:
- Retrospective observational study of ICU patients requiring isolation for over 48 hours.
- Data collected from electronic medical records over a two-year period.
- Utilized Modular Review Form questionnaires to assess PSIs and adverse events (AEs).
Main Results:
- 76 patients included; 74 experienced at least one PSI.
- 798 PSIs detected, with 511 during isolation; 199 were adverse events.
- Most frequent PSIs involved medication and healthcare, with high preventability.
Conclusions:
- Patient safety incidents are common in ICUs and largely preventable.
- Isolation precautions were not found to be a risk factor for PSIs.
- Enhancing patient safety culture is vital for effective prevention strategies.
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