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UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems
Hagar Malcov-Brog1, Ayelet Alpert2, Tamar Golan1
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Molecular Cell
|November 8, 2018
Summary
Skin
Area of Science:
- Dermatology and Molecular Biology
- Skin physiology and UV response
Background:
- Sun exposure triggers rapid stress responses and delayed pigmentation in skin.
- Coordination between these two protective programs is not well understood.
Purpose of the Study:
- To investigate the coordination between skin stress responses and pigmentation.
- To elucidate the role of MITF in synchronizing these programs and acting as a UV-protection timer.
Main Methods:
- Mathematical modeling and empirical studies were employed.
- Analysis of MITF dynamics, including transcriptional (HIF1α) and post-transcriptional (microRNA-148a) regulatory loops.
Main Results:
- UVB exposure every other day enhanced skin pigmentation more than daily exposure, without increasing stress.
- MITF acts as a synchronizer and timer for UV protection, exhibiting damped oscillatory dynamics.
- Negative feedback loops involving HIF1α and microRNA-148a regulate MITF oscillations.
Conclusions:
- MITF synchronizes skin stress responses and pigmentation through oscillatory dynamics, creating a trade-off.
- These findings suggest a linked evolutionary trait for furless skin to minimize UV damage.
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