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An update on pulmonary and neurodevelopmental outcomes of bronchopulmonary dysplasia

Jeanie L Y Cheong1, Lex W Doyle2

  • 1Neonatal Services, Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Australia; Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia.

Seminars in Perinatology
|November 8, 2018
PubMed

Insights

Bronchopulmonary dysplasia (BPD), a complication of extreme prematurity, persists despite intensive care. Reducing BPD rates is crucial for improving long-term health and development in preterm infants.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Developmental Pediatrics

Background:

  • Bronchopulmonary dysplasia (BPD) is a prevalent complication in extremely preterm infants.
  • Despite advancements in perinatal care, BPD incidence remains high.
  • BPD significantly impacts long-term respiratory and neurodevelopmental outcomes.

Purpose of the Study:

  • To highlight the persistent challenges and long-term consequences of bronchopulmonary dysplasia.
  • To underscore the need for improved strategies to reduce BPD rates in extremely preterm infants.

Main Methods:

  • This abstract summarizes existing knowledge on BPD outcomes.
  • It reviews data on respiratory health, cognitive development, and academic progress in BPD survivors.

Main Results:

  • Neonatal BPD is associated with increased respiratory hospitalizations in early childhood.
  • Children with BPD exhibit higher rates of childhood asthma and airway obstruction into adulthood.
  • Survivors show poorer motor function, cognitive development, and academic achievement.

Conclusions:

  • Bronchopulmonary dysplasia poses significant, lasting health challenges for extremely preterm infants.
  • Substantial reduction in BPD rates is essential for improving long-term outcomes.
  • Further research and clinical advancements are needed to mitigate BPD's impact.

Keywords:
Bronchopulmonary dysplasialong-term outcomesneurodevelopmentpreterm

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