Incorporating newer agents in the treatment of acute myeloid leukemia

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Renju V Raj1, Sameem M Abedin1, Ehab Atallah1

  • 1Divison of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.

Leukemia Research
|November 8, 2018
PubMed

Insights

The prognosis for acute myeloid leukemia (AML) patients has improved with new FDA-approved therapies like CPX-351 and midostaurin. This review summarizes recent advancements in AML treatment strategies.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Prognosis for acute myeloid leukemia (AML) remains poor.
  • Limited therapeutic progress for non-APL AML despite decades of research.

Purpose of the Study:

  • To review new FDA-approved therapies for AML.
  • To discuss the evolving landscape of AML treatment.

Main Methods:

  • Literature review of recent clinical trials and FDA approvals.
  • Synthesis of data on novel AML therapeutics.

Main Results:

  • Several new therapies, including CPX-351, midostaurin, gemtuzumab ozogamicin, enasidenib, and ivosidenib, show efficacy in AML.
  • These agents have received FDA approval for AML treatment.

Conclusions:

  • Recent therapeutic advancements offer improved options for AML patients.
  • The treatment landscape for AML is rapidly changing with new drug approvals.
Keywords:
AMLCPX-351GemtuzumabIDH inhibitorMidostaurinVenetoclax

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