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Updated: Feb 2, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Exploring Seipin: From Biochemistry to Bioinformatics Predictions
Aquiles Sales Craveiro Sarmento1, Lázaro Batista de Azevedo Medeiros1, Lucymara Fassarella Agnez-Lima1
1Laboratório de Biologia Molecular e Genômica, Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Abstract:
Seipin is a nonenzymatic protein encoded by the BSCL2 gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed features of seipin expression disorders. Likewise, this review shows how this protein seems to have tissue-specific functions. In an integrative view, we conclude by proposing a theoretical model to explain how seipin might be involved in the triacylglycerol synthesis pathway.
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