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Extracorporeal Life Support in Organ Transplant Donors

Wonho Chang1

  • 1Department of Thoracic and Cardiovascular Surgery, Soonchunhyang University Seoul Hospital.

The Korean Journal of Thoracic and Cardiovascular Surgery
|November 8, 2018
PubMed

Insights

Extracorporeal life support (ECLS) effectively preserves organs from brain-dead donors, expanding the donor pool. This method demonstrated significant benefits and excellent early clinical outcomes in transplantation.

Area of Science:

  • Transplantation Medicine
  • Critical Care Medicine
  • Organ Preservation

Background:

  • Extracorporeal life support (ECLS) offers a method for organ perfusion in brain-dead donors.
  • Utilizing ECLS can potentially expand the deceased donor organ pool for transplantation.

Purpose of the Study:

  • To evaluate the benefits of ECLS for organ preservation in potential donors.
  • To assess the early clinical outcomes of organ recipients following ECLS use in donors.

Main Methods:

  • Retrospective analysis of 9 patients receiving ECLS between June 2012 and April 2017.
  • Data collected included demographics, ECLS purpose/duration, cause of death, vasoactive drug use, and pre-retrieval dialysis.
  • Recipient outcomes, graft function, and survival at 1 month were studied.

Main Results:

  • ECLS was used for cardiopulmonary resuscitation or hemodynamic support during brain death assessment.
  • A total of 18 kidneys, 7 livers, and 1 heart were successfully retrieved and transplanted from 9 donors.
  • No organs were discarded; only one instance of delayed kidney graft function occurred, with all 26 recipients discharged without major complications.

Conclusions:

  • ECLS provides significant benefits for protecting donor vital organs.
  • ECLS is a viable and widely applicable technique in organ preservation for transplantation.
Abstract

Keywords:
Extracorporeal membrane oxygenationTissue and organ procurementTransplantation

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