Related Experiment Video
Updated: Feb 2, 2026

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
Published on: March 10, 2016
Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial
Tatyana I Eliseeva1, Svetlana V Krasilnikova2, Sergey Yu Babaev3
1MD, DSc, Professor, Chair of Hospital Pediatrics, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod 603005, Russia.
Insights
Nasal obstructive disorders, particularly enlarged pharyngeal tonsils, significantly impact nasal airflow measurements in children with asthma and allergic rhinitis. This finding is crucial for accurate clinical assessments.
Area of Science:
- Pediatric Pulmonology
- Otolaryngology
- Allergy and Immunology
Background:
- Atopic bronchial asthma (BA) in children frequently co-occurs with upper airway pathologies (UAP).
- Common UAP include allergic rhinitis (AR) and nasal obstructive disorders (NOD), such as hypertrophy of the pharyngeal tonsil (HPT) and anomalies of intranasal structures (AINS).
- Anterior active rhinomanometry (AARM) is vital for assessing nasal patency in these patients.
Purpose of the Study:
- To determine the influence of nasal obstructive disorders (NOD) on rhinomanometric parameters in children with bronchial asthma and allergic rhinitis.
Main Methods:
- Sixty-six children with BA and AR underwent AARM, rhinovideoendoscopy, spirometry, and clinical evaluations.
- A specialized index of reduced total nasal airflow was employed to mitigate the impact of anthropometric and age-related variations on AARM results.
Main Results:
- NOD, particularly HPT, significantly impair AARM indices during both AR remission and exacerbation phases.
- The impact of AINS on AARM was less pronounced, becoming notable primarily when co-occurring with HPT.
Conclusions:
- Hypertrophy of the pharyngeal tonsil is a key factor negatively affecting nasal airflow measurements in children with asthma and allergic rhinitis.
- Clinical interpretation of AARM in pediatric BA patients with nasal symptoms must account for the presence and severity of NOD.
Background:
Atopic bronchial asthma (BA) in children is associated with upper airways pathology (UAP). Among them, a combination of allergic rhinitis (AR) and nasal obstructive disorders (NOD), including hypertrophy of the pharyngeal tonsil (HPT) and anomalies of the intranasal structures (AINS), is abundant. In such patients, anterior active rhinomanometry (AARM) is an important method of examining nasal patency. However, NOD can influence the AARM parameters in children with BA and nasal symptoms, and this effect must be taken into account in clinical practice. Study goal was to elucidate the effect of NOD on rhinomanometric parameters in this group of patients.
Methods:
Total of 66 children with BA and AR were examined with AARM, rhinovideoendoscopy, spirometry, and standard clinical tests allowing revealing the structure of comorbid pathologies. In order to avoid the influence of anthropometric parameters of children and their age on AARM parameters, a special index of reduced total nasal airflow was used.
Results:
It has been established that NOD, especially HPT, have a significant negative impact on the indices of anterior active rhinomanometry during the periods of both AR remission and AR exacerbation. The effect of AINS is much weaker and was remarkable only in combination with HPT.
Related Concept Videos
Asthma-III: Symptoms and Complications
Classification of Asthma
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Nose and Nasal Cavity
Diabetes: Symptoms, Diagnosis, and Complications
Administering Oxygen by Nasal Cannula
Nasal Cannulas
A nasal cannula is a lightweight tube split into two prongs placed in the nostrils,...
Oxygen Delivering System I: Nasal Cannula and Face Mask
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...

