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Updated: Feb 2, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity
Edith Fabiola Martínez-Pérez1,2, Zaida N Juárez3, Luis R Hernández2
1Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6.
Abstract:
Natural products with antispasmodic activity have been used in traditional medicine to alleviate different illnesses since the remote past. We searched the literature and compiled the antispasmodic activity of 248 natural compounds isolated from terrestrial plants. In this review, we summarized all the natural products reported with antispasmodic activity until the end of 2017. We also provided chemical information about their extraction as well as the model used to test their activities. Results showed that members of the Lamiaceae and Asteraceae families had the highest number of isolated compounds with antispasmodic activity. Moreover, monoterpenoids, flavonoids, triterpenes, and alkaloids were the chemical groups with the highest number of antispasmodic compounds. Lastly, a structural comparison of natural versus synthetic compounds was discussed.
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