Related Experiment Video
Updated: Feb 2, 2026
10:24
A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
9
Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity
Edith Fabiola Martínez-Pérez1,2, Zaida N Juárez3, Luis R Hernández2
1Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6.
Biomed Research International
|November 8, 2018
Summary
Natural products from plants, particularly Lamiaceae and Asteraceae families, show significant antispasmodic activity. This review details 248 compounds, highlighting monoterpenoids, flavonoids, triterpenes, and alkaloids for potential therapeutic use.
Area of Science:
- Pharmacology and Natural Product Chemistry
Background:
- Natural products have a long history in traditional medicine for treating various ailments.
- Antispasmodic agents are crucial for managing conditions involving smooth muscle spasms.
Purpose of the Study:
- To comprehensively review and summarize natural products with documented antispasmodic activity.
- To identify plant families and chemical classes rich in antispasmodic compounds.
- To provide chemical and methodological details of identified compounds.
Main Methods:
- Extensive literature search for natural products with antispasmodic activity reported up to 2017.
- Compilation of chemical information, extraction methods, and bioassay models.
- Analysis of plant families and chemical structures of active compounds.
Main Results:
- A total of 248 natural compounds with antispasmodic activity from terrestrial plants were identified.
- Lamiaceae and Asteraceae families yielded the highest number of antispasmodic compounds.
- Monoterpenoids, flavonoids, triterpenes, and alkaloids were the most prevalent chemical groups.
Conclusions:
- Terrestrial plants are a rich source of natural antispasmodic compounds.
- Specific plant families (Lamiaceae, Asteraceae) and chemical classes (monoterpenoids, flavonoids, triterpenes, alkaloids) are promising for drug discovery.
- Further research into structure-activity relationships of these natural compounds is warranted.
Related Concept Videos
01:12Stereochemical Effects of Enolization
2.6K
The chiral α-carbon of the carbonyl compound is the stereocenter of the molecule. As shown in the figure below, when such a carbonyl compound undergoes racemization under an acidic or basic condition, an achiral enol is formed.
2.6K
01:22Controller Configurations
380
Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation.
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
380
02:46Electron Configurations
26.3K
Electron configurations and orbital diagrams can be determined by applying the Aufbau principle (each added electron occupies the subshell of lowest energy available), Pauli exclusion principle (no two electrons can have the same set of four quantum numbers), and Hund’s rule of maximum multiplicity (whenever possible, electrons retain unpaired spins in degenerate orbitals).
The relative energies of the subshells determine the order in which atomic orbitals are filled (1s, 2s, 2p, 3s, 3p,...
The relative energies of the subshells determine the order in which atomic orbitals are filled (1s, 2s, 2p, 3s, 3p,...
26.3K
03:26Electron Configuration of Multielectron Atoms
65.0K
The alkali metal sodium (atomic number 11) has one more electron than the neon atom. This electron must go into the lowest-energy subshell available, the 3s orbital, giving a 1s22s22p63s1 configuration. The electrons occupying the outermost shell orbital(s) (highest value of n) are called valence electrons, and those occupying the inner shell orbitals are called core electrons. Since the core electron shells correspond to noble gas electron configurations, we can abbreviate electron...
65.0K
01:57What is Conservation Biology?
24.3K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
01:16Configurations of BJT
1.1K
Bipolar Junction Transistors (BJTs) are categorized into various types based on their configurations, each with distinct characteristics and applications. The configurations are primarily differentiated by which terminal—base, emitter, or collector—is common to both the input and output circuits.
The common base configuration is noted for its high voltage gain, positioning it as an ideal choice for single-stage amplifier circuits, such as microphone pre-amplifiers. A notable...
The common base configuration is noted for its high voltage gain, positioning it as an ideal choice for single-stage amplifier circuits, such as microphone pre-amplifiers. A notable...
1.1K