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Therapeutic Targets for Adrenocortical Carcinoma in the Genomics Era

Dipika R Mohan1,2, Antonio Marcondes Lerario3, Gary D Hammer3,4,5,6

  • 1Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan.

Journal of the Endocrine Society
|November 8, 2018
PubMed

Insights

Adrenocortical carcinoma (ACC) research reveals three distinct molecular subtypes with different outcomes. Understanding these subtypes and their associated pathways offers new therapeutic targets for this rare cancer.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Adrenocortical carcinoma (ACC) is a rare, aggressive cancer with poor prognosis.
  • Limited effective therapies exist, emphasizing the need for deeper molecular understanding.

Purpose of the Study:

  • To review historical genetics and recent genomics findings in ACC.
  • To integrate these findings into a model of adrenocortical carcinogenesis.
  • To identify potential therapeutic targets.

Main Methods:

  • Review of historical genetics studies.
  • Analysis of recent genomics data.
  • Integrative synthesis of molecular findings.

Main Results:

  • ACC exhibits three distinct molecular subtypes with varying clinical outcomes.
  • Key pathways implicated include Wnt signaling, cell cycle, DNA methylation, immune biology, and steroidogenesis.
  • These pathways are pharmacologically targetable.

Conclusions:

  • Molecular subtyping provides a framework for understanding ACC heterogeneity.
  • Targeting identified cellular programs may lead to novel therapeutic strategies.
  • Improved understanding of ACC molecular biology is crucial for developing better treatments.
Keywords:
adrenaladrenocortical carcinomagenomicstargeted therapy

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