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[Pathogenesis and diagnostic evaluation of Fuchs' endothelial corneal dystrophy]
K Wacker1, T Reinhard2, P Maier2
1Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland. katrin.wacker@uniklinik-freiburg.de.
Summary
Clinical evaluation for Fuchs
Area of Science:
- Ophthalmology
- Corneal Disease Research
Background:
- Fuchs' endothelial corneal dystrophy (FECD) understanding is evolving with new treatments.
- Corneal structural and optical changes in FECD patients are increasingly recognized.
Purpose of the Study:
- To update the clinical evaluation methods for Fuchs' dystrophy.
- To address the progressive nature of FECD and its impact on corneal layers.
Main Methods:
- Discussing standardized approaches for evaluating FECD in clinical practice and research.
- Considering progressive and irreversible structural changes in all corneal layers.
Main Results:
- Early corneal structural changes in FECD are detectable before clinical edema.
- Optical limitations can be quantified using acuity, glare, and contrast sensitivity tests.
- Patient-reported outcomes, like the V-FUCHS instrument, assess vision-related limitations.
Conclusions:
- Current clinical grading of Fuchs' dystrophy (edematous/non-edematous stages) is outdated.
- Improved therapies necessitate standardized assessment of optical, structural, and patient-reported changes in FECD.
