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ERCC polymorphisms and risk of osteosarcoma: a meta-analysis.
1The Department of Bone Diseases, Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, China. liangdongld123@163.com.
European Review for Medical and Pharmacological Sciences
|November 8, 2018
Summary
The ERCC2 rs1799793 gene variant is linked to an increased risk of osteosarcoma. This finding clarifies the controversial association between excision repair cross-complementation genes and bone cancer development.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The role of excision repair cross-complementation (ERCC) genes, specifically ERCC1 and ERCC2, in osteosarcoma risk has been debated.
- Understanding these genetic associations is crucial for identifying individuals at higher risk for osteosarcoma.
Purpose of the Study:
- To systematically analyze and evaluate the association between ERCC1 and ERCC2 gene polymorphisms and the risk of developing osteosarcoma.
- To resolve the existing controversy regarding the link between ERCC genes and osteosarcoma.
Main Methods:
- A comprehensive meta-analysis of relevant case-control studies was conducted.
- Studies were identified through electronic database searches updated until March 2017.
- Study quality was assessed using the Newcastle-Ottawa Scale, and meta-analysis was performed using R software.
Main Results:
- The analysis included 4 case-control studies with 1208 cases and 2448 controls.
- A significant association was found between the ERCC2-rs1799793 polymorphism (AA+AC vs. CC) and an increased risk of osteosarcoma (OR=1.3428, 95% CI=1.0201; 1.7674).
- No significant associations were observed for other studied ERCC single nucleotide polymorphisms (SNPs), including ERCC1 rs3212986, ERCC1 rs11615, and ERCC2 rs13181.
Conclusions:
- The ERCC2 rs1799793 polymorphism is significantly associated with an elevated risk of osteosarcoma development.
- This finding provides important genetic insights into osteosarcoma etiology.
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